SINTESIS ANALOG 4-BROMO PIRAZOLIN DARI KALKON INTI NAFTALEN DENGAN KATALIS ASAM DAN UJI AKTIVITAS NYA SEBAGAI ANTIBAKTERI

Abstract

Pyrazolines have been reported to possess  various  biological activities such as antimicrobial,  antidepressant,  antidiabetic,  anti-inflammatory,  antipyretic,  anticancer, and  anticonvulsant  activity. In this research, a halogenated pirazoline 5-(4-bromophenyl)-3-(naphthalene-1-yl)-4,5-dihydro-1H-pyrazole was synthesized  by cyclization  reaction between chalchone with hydrazine  hydrate  using acetate acid as
catalyst under microwave irradiation. The compound showed a good yield, and then was characterized by  UV,  IR, 1H-NMR, and
13C-NMR spectroscopy. The antibacterial activity of pyrazolines was determined using the agar diffusion method  against  Gram-negative bacteria:  Escherichia  coli  and  Salmonella  typhi  and  Gram-positive bacteria: Bacillus  subtilis  and  Staphylococcus  aureus. This compound  showed  inhibitory  activity against those four bacteria. Test results of antibacterial activity indicated that pyrazoline analogues were potential as antibiotics.