GAMBARAN HISTOPATOLOGI ARTERI KORONARIA TIKUS PUTIH JANTAN GALUR WISTAR SETELAH PEMBERIAN DIET ATEROGENIK SELAMA DELAPAN MINGGU

Abstract

ABSTRACT
Atherosclerosis could be induced by feeding rats aterogenik diet
containing high cholesterol and colic acid. For increasing atherosclerosis process
vitamin D3 also given orally. Aim this research has an aims to analyze the
difference of coronary artery histopathologycal image between white rat strain
wistar feeding by aterogenic diet and standard diet for 8 weeks. This is an
experimental laboratory research with post test only design. This research used
twelve rats were segregated into two groups (n=6) labeled ads control; fed
standard diet and atherogenik fed diet ( containing colic acid 0,2%, fat 5%, and
yolk 2%) and vitamin D3. The statistic test result do not show a significant
difference of atherogenic score of control group and atherogenic group. As the
conclusion, feeding atherogenic diet for 8 weeks can induce the formation of
accumulation of extracellular lipid in all samples of coronary artery of white rats,
atheroma in 3 samples and thrombus 1 samples, while feeding standard diet just
so atherosclerosis process on 4 samples, the formation of accumulation of
intracellular lipid in 1 samples and atheroma in 3 sample.
Keywords : atherosclerosis, histopathology, atherogenic diet