HUBUNGAN LAMA PEMBERIAN DIET ATEROGENIK TERHADAP KADAR TRIGLISERIDA Rattus novergicus JANTAN STRAIN WISTAR

Abstract

ABSTRACT
Cardiovascular diseases is the disruption and damage of the heart muscle
and the number one cause of death worldwide. Based on epidemiologic data and
clinical trial results support an association between elevated triglyceride and
Cardiovascular risk. The goal of this research is to know the correlation of given
duration atherogenic diet againts triglyceride level in male wistar rats. This
research was experimental with the post test-only control group design, by using
male rats (Rattus novergicus) of 2-3 month with the average weight range of 160-
240 g. The rats were divided into 4 group, control group given with standard diet,
the 5 weeks atherogenic diet group, the 8 weeks atherogenic group and 12 weeks
atherogenic group, in which group consist of 6 rats. The atherogenic diet (2%
cholesterol of yolk, 5% goat’s fat, and 0,2% cholic acid) were given as much as
20 g/each/day. The result showed a significant difference (p=0,000). As for the
post hoc test (p=0,000), there is a statistically significant difference within the
experimental groups. As for the spearman test (0,969), it shows a significant
positive correlation between the given duration of the atherogenic diet and the
triglyceride level. It can be concluded the longer time that the rats got
atherogenic diet showed the level of triglycerides rats (Rattus novergicus)
increased.
Keywords: Atherogenic diet, triglyceride level, rats (Rattus novergicus).